Diels.Common Name(s): Chinese angelica, Danggui, Dong quai, Tang-kuei. Warfarin (Coumadin) interacts with DONG QUAI. Zhu DP. Dong quai side effects Get emergency medical help if you have any of these signs of an allergic reaction : hives ; difficult breathing; swelling of your face, lips, tongue, or throat. Am J Health Syst.Pharm 2-15-2002;59(4):339-347. Clinical trials supporting traditional uses are limited. Dong Quai vs Other Similar Plants. 2010;7(11):3695-3714. Life Sci 6-29-2001;69(6):637-646. Hirata JD, Swiersz LM, Zell B, et al. (Alacare March 2015, Ameluz May 2016, Drucker 2011, Ladner 2001, Lankerani 2004, Levulan March 2010, Naldi 1999), Anticoagulants: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of anticoagulants. Medically reviewed by Drugs.com. View abstract. Treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction. View abstract. J Nutr 2003;133(11 Suppl 1):3785S-3793S. Hypertension in mother and baby linked to ingestion of Chinese herbal medicine. Clin Cancer Res 5-1-2005;11(9):3475-3484. There was also no difference between dong quai and placebo groups for prostate-specific antigen levels and digital rectal examination results during the 3-month study.Al-Bareeq 2010. Side Effects. View abstract. It is promoted for similar uses in the American herb market.Haines 2008, The chemistry of A. sinensis is distinct from that of other species in the genus. Russell, L., Hicks, G. S., Low, A. K., Shepherd, J. M., and Brown, C. A. Phytoestrogens: a viable option? View abstract. 1991;104(9):776-781. Goy SY and Loh KC. Studies on the antitumor-promoting activity of naturally occurring substances. Smooth purple-colored stems and umbrella-shaped white flowers characterize dong quai. Mei, Q. Eagon PK, Elm MS, Hunter DS, et al. J Tradit.Chin Med 1986;6(3):187-190. Phytomedicine. View abstract. View abstract. Potential interactions between alternative therapies and warfarin. Singapore Medical Journal 2001;42(3):115-116. View abstract. 2012;37(22):3350-3353. View abstract. It is often combined with other herbs in formulations. Wang H, Li W, Li J, et al. HealthFacts 1998;23(2):5. View abstract. View abstract. View abstract. The daily suggested use of Dong Quai is 30 drops, 2 times a day in a little water. Eagon PK, Elm MS, Hunter DS, and et al. Dong quai can also slow blood clotting. Hudson TS, Standish L, Breed C, and et al. Zhongguo Zhong.Yao Za Zhi. Bleeding may occur. J Br Menopause.Soc 2004;10(4):162-165. [The effect of angelica polysaccharide on proliferation and differentiation of hematopoietic progenitor cell]. Avoid use. In a clinical trial investigating use in menopause, dong quai 4.5 g was administered daily for 24 weeks. Clinical study of SS-Cream in patients with lifelong premature ejaculation. The compounds were characterized as nonspecific antispasmodics with a mechanism different from that of papaverine.Ko 1980, In vitro experiments evaluating A. sinensis extracts found induced apoptosism activity against cervical and hepatocellular carcinoma and leukemia cell linesChen 2007, Chae 2004 and inhibitory actions against a number of tumors.Lee 2006, Tsai 2005, A large, prospective observational study in postmenopausal women during a 7-year period found that dong qui use was not associated with an increased risk of breast cancer (hazards ratio 1.27 [95% confidence interval, 0.76 to 2.13]), but the number of patients reporting use was less than 500 out of a study population of more than 30,000 patients.Brasky 2010, The furocoumarin phellopterin has been characterized as a competitive partial agonist of central benzodiazepine receptors by gamma-aminobutyic acid (GABA) and TBPS shift assaysDekermendjian 1996 and to bind with high affinity to benzodiazepine receptors in vitro; however, other closely related furocoumarins were weaker or inactive.Bergendorff 1997 The ligustilide and butylidenephthalide constituents of Japanese angelica root may exert central noradrenergic or GABA activity.Matsumoto 1998, In vivo animal studies suggest that the basis for dong quai use in dysmenorrhea lies in its action of increasing excitability of the uterus; the rhythm of contraction changed from fast, weak, and irregular to slow, strong, and more regular. Summary. View abstract. View abstract. Kan, W. L., Cho, C. H., Rudd, J. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DONG QUAI. CONDITIONS OF USE AND IMPORTANT INFORMATION: Unfortunately, there just isn't enough solid science to back up the use of dong quai for these purposes. View abstract. Nurse Pract. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Burke BE, Olson RD, Cusack BJ. Dong quai and its chemical constituents possess antiasthmatic, antispasmodic, anti-inflammatory, and anticoagulant properties. Endometriosis 200 mg of standardized extract or 1/2 tsp. anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng. Tanaka, S., Ikeshiro, Y., Tabata, M., and Konoshima, M. Anti-nociceptive substances from the roots of Angelica acutiloba. Xu, J. and Li, G. [Observation on short-term effects of Angelica injection on chronic obstructive pulmonary disease patients with pulmonary hypertension]. The recommended daily dose for the powder form is 1,000 mg once or twice per day. View abstract. Postgrad Med J 2005;81:266-7.. View abstract. View abstract. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Okuyama, T., Takata, M., Nishino, H., Nishino, A., Takayasu, J., and Iwashima, A. Zhao, L., Zhang, Y., and Xu, Z. X. Imported Dong Quai Root (Angelica sinensis) is a powerful Chinese tonic herb which has an adaptogenic effect on the female hormonal system. Relative contraindications in patients receiving warfarin, heparin, or other anticoagulant/antiplatelet therapy, in those with breast cancer, or in the first trimester of pregnancy. In combination, dong quai 100 mg standardized to 1% ligustilide was similarly used daily.Burke 2002, Hirata 1997, Haimov-Kochman 2005, Lau 2005, The content of A. sinensis in some commercially available preparations has been questioned.Hook 2014, Avoid use.Brinker 1998 Uterine stimulant and relaxant activity have been reported with A. sinensis, while a related species, Angelica archangelica L., was a reported abortifacient and affected the menstrual cycle.Ko 1980, Studies indicate A. sinensis extracts increase liver CYP2D6 and CYP3A4 activity, with potential for herb-drug interactions.Hook 2014, Agents with antiplatelet properties: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of agents with antiplatelet properties. Medicinal herbs: modulation of estrogen action. Dong Quai Dosage and Instructions. For endometriosis, try taking three to four grams of dong quai daily for its anti-inflammatory and anti-spasmodic effects. Yamada, H., Komiyama, K., Kiyohara, H., Cyong, J. C., Hirakawa, Y., and Otsuka, Y. 1994;14(2):71-3, 67. Amato P, Christophe S, Mellon PL. View abstract. J Ethnopharmacol. J.Am.Pharm.Assoc.(2003.) Dong quai is an herb, the root of which has been used in traditional Chinese medicine for thousands of years. Altern Med Rev 2004;9:429-33. If you have diarrhea, check with your doctor before taking dong quai. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Consider therapy modification.Mousa 2010, Spolarich 2007, Stanger 2012, Ulbricht 2008, Tsai 2013, Verteporfin: Photosensitizing agents may enhance the photosensitizing effect of verteporfin. 2010;50(5):e106-e115. Ann.Allergy Asthma Immunol. Lau CBS, Ho TCY, Chan TWL, Kim SCF. Shi, Y. M. and Wu, Q. Herbs of special interest to women. sinensis (Oliv.). It is used primarily for health issues in women and has been termed "female ginseng." Dong Quai is a herb that is seen as exceptionally nourishing to a weakened and depleted state, even in extremis. Phytother.Res. 500 mg of an … MMWR Morb.Mortal.Wkly.Rep. Gynaecomastia and the herbal tonic "Dong Quai". Chem.Pharm Bull. Low, Dog T. Menopause: a review of botanical dietary supplements. 2012;107(5):712-718. This survey is being conducted by the WebMD marketing sciences department. Am.J Chin Med 1997;25(2):205-212. Chin Med J (Engl.) This information relates to an herbal, vitamin, mineral or other dietary supplement. View abstract. Scott, G. N. and Elmer, G. W. Update on natural product--drug interactions. View abstract. Sung, C. P., Baker, A. P., Holden, D. A., Smith, W. J., and Chakrin, L. W. Effect of extracts of Angelica polymorpha on reaginic antibody production. The Chinese people discovered Dong Quai and used it as a tonic and spice. Noé J. All rights reserved. Am Fam.Physician 2-1-2006;73(3):457-464. Am J Med Sci 2002;324(4):185-188. Wang, Y. and Zhu, B. 2006;20(8):665-669. Planta Med 2000;66(4):348-351. Kumazawa, Y., Mizunoe, K., and Otsuka, Y. Immunostimulating polysaccharide separated from hot water extract of Angelica acutiloba Kitagawa (Yamato tohki). Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. (Tokyo) 1990;38(4):1084-1086. J Nat Prod 1982;45(4):398-406. Choi HK, Jung GW, Moon KH, et al. Keep in mind that natural products are not always necessarily safe and dosages can be important. Did you or will you purchase this product in-store or online? Aust J Med Herbalism 1993;5(4):87-91. May Reduce Blood Sugar. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. At this time there is not enough scientific information to determine an appropriate range of doses for dong quai. View abstract. Dong quai root extract is commonly used as an oral supplement in the form of powder. Chinese Pharmaceutical Journal 2006;41(8):577-580. Inhibitory Effects of Angelica Polysaccharide on Activation of Mast Cells. The Herbal Alternatives for Menopause (HALT) Study: background and study design. 6-1-2001;61(11):1439-1448. You can find dong quai … Menopausal symptoms. European Journal of Herbal Medicine 1996;2(2):20-26. Warfarin (Coumadin) is used to slow blood clotting. Does dong quai have estrogenic effects in postmenopausal women? Ailments-Dosage. View abstract. The risk of phototoxicity should be correlated with the content of specific toxic furocoumarins; in the case of A. sinensis, the risk appears to be limited.Kronenberg 2002, Haimov-Kochman 2005, Hann 1991, Leung 1996, Fever was reported in a clinical trial.Page 1999, Hypertension has been reported with the use of this herb.Jalili 2013, A case of gynaecomastia was reported, but causality is unclear.Goh 2001 The possibility of dong quai tablet contamination has been raised.Fugh-Berman 2003, Kiong 2001, In the 2016 Scientific Statement by the American Heart Association regarding drugs that may cause or exacerbate heart failure, dong quai has been recognized as a product with anticoagulant effects which may increase bleeding risk when used with anticoagulants.