The neurobiological effects of physical exercise are numerous and involve a wide range of interrelated effects on brain structure, brain function, and cognition. I asked Ram what he thought about this study and he said: "It is an interesting study no doubt, but it's using mouse models. The inherent complexity of the CNS, and the methodologic difficulties in evaluating its in vivo neurochemistry in humans, provide challenges to investigators studying the impact of exercise on the CNS. Exercise can have profound effects on numerous biologic systems within the human body, including the central nervous system (CNS). 1. The central nervous system is involved every time you exercise. Exercise can have profound effects on numerous biologic systems within the human body, including the central nervous system (CNS). Wow, that is a lot of negative effects from lack of exercise! Inducing the effects of the sympathetic nervous system for its benefits also has its time and place. Known as central nervous system (CNS) fatigue, this condition is marked by decreased functioning in the part of the brain responsible for voluntary movement. Effects of physical exercise on central nervous system functions: a review of brain region specific adaptations Julie A Morgan1, Frances Corrigan2 and Bernhard T Baune1* Abstract Pathologies of central nervous system (CNS) functions are involved in prevalent conditions such as Alzheimer’s disease, depression, and Parkinson’s disease. Multiple sclerosis (MS) is a central nervous system (CNS) disorder characterized by inflammation, demyelination, and neurodegeneration. Its main function is to interpret stimuli from your eyes, ears, muscles and other receptor organs and send these interpretations back to organs that carry out an appropriate response. The β-endorphin (β-EP) in central nervous system is thought to play an important role in physical exercise. A 2005 study published in Current Sports Medicine Reports, points out that regular exercise has profound effects on numerous biologic systems in the body, including the central nervous system, and can influence psychological well-being and cognitive function. An opposing model4 holds that exercise performance is regulated by the central nervous system (CNS) to ensure that homeostasis is maintained, both at rest and during exercise, in all bodily systems, specifically to preclude any catastrophic biological failure. Of Mice and Men. Interesting scientific studies are still being made on a daily basis about the importance of exercise for brain and nervous system health. While some people debate what causes it (and others deny its existence altogether), many athletes and active individuals have struggled with the long-term side effects of CNS fatigue. Any intense exercise you do within the 48-hour window can potentially create more drain on your system and set you back further. However, its expression patterns and physiological effects in the central nuclei under different exercise states are not well understood. The only ways to recover completely are to sleep and give your body time to rest. Emerging research suggests that exercise has therapeutic benefits for MS patients but the clinical data have focused primarily on non‐CNS outcomes. If you find yourself constantly exhausting your central nervous system, it may be time to switch up your workout schedule.